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KMID : 1004820100110030175
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Journal of Biomedical Research
2010 Volume.11 No. 3 p.175 ~ p.183
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Four-Week Repeated-Dose Toxicity of a Magnolia Ethanol Extract in Rats
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Yang Yun-Hui
Yang Go-Eun
Park Dong-Sun
Lee Sun-Hee
Bae Dae-Kwon
Kim Tae-Kyun
Choi Young-Jin
Choi Ehn-Kyoung
Kim Yun-Bae
Hwang Seock-Yeon
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Abstract
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This study was conducted in order to investigate repeated-dose toxicities of Magnolia ovobata ethanol extract (MEE). MEE was administered orally to male and female Sprague Dawley rats at dose levels of 0, 500, 1,000, or 2,000 mg/kg for four weeks. Repeated administration of MEE did not induce abnormalities in general signs, body weight gain, feed and water consumption, necropsy findings, or organ weights. In addition, no abnormality was observed in hematological analyses; red blood cells and their indices, white blood cells, platelets, and coagulation times. In male rats, BUN and creatinine showed an increase at doses of 2,000 mg/kg and 500-1,000 mg/kg, respectively, while in female rats, lactate dehydrogenase and creatine phosphokinase showed a decrease at 2,000 mg/kg, the upper-limit dose of repeated-dose toxicity studies. However, there were no dose-dependent increases or gender-relationship. In addition, other parameters of the hepatic and muscular toxicities as well as energy and lipid metabolism were not affected. In microscopic examination, no considerable pathological findings were observed. The results indicate the safety of oral administration of MEE to the upper-limit dose.
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KEYWORD
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Magnolia ethanol extract, Repeated-dose toxicity, Safety
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